250 320
Guidelines
What Is the Negative Predictive Value of Multiparametric
Magnetic Resonance Imaging in Excluding Prostate Cancer at
Biopsy? A Systematic Review and Meta-analysis from the
European Association of Urology Prostate Cancer Guidelines Panel
Paul C. Moldovan
a ,y
[1_TD$DIFF]
, Thomas Van den Broeck
b , c , y[1_TD$DIFF]
, Richard Sylvester
d ,Lorenzo Marconi
e ,Joaquim Bellmunt
f , g ,Roderick C.N. van den Bergh
h ,Michel Bolla
i ,Erik Briers
j ,Marcus G. Cumberbatch
k ,Nicola Fossati
l ,Tobias Gross
m, Ann M. Henry
n ,Steven Joniau
b , c ,Theo H. van der Kwast
o ,Vsevolod B. Matveev
p ,Henk G. van der Poel
h ,Maria De Santis
q ,Ivo G. Schoots
r , s ,Thomas Wiegel
t ,Cathy Yuhong Yuan
u ,Philip Cornford
v ,Nicolas Mottet
w ,Thomas B. Lam
x , y ,Olivier Rouvie`re
a , z , *a
Hospices Civils de Lyon, Department of Urinary and Vascular Radiology, Hoˆpital Edouard Herriot, Lyon, France;
b
Department of Urology, University
Hospitals Leuven, Leuven, Belgium;
c
Laboratory of Molecular Endocrinology, KU Leuven, Leuven, Belgium;
d
European Association of Urology Guidelines
Office, Brussels, Belgium;
e
Department of Urology, Coimbra University Hospital, Coimbra, Portugal;
f
Bladder Cancer Center, Dana-Farber Cancer Institute,
Boston, MA, USA;
g
Harvard Medical School, Boston, MA, USA;
h
Department of Urology, Netherlands Cancer Institute, Amsterdam, The Netherlands;
i
Department of Radiation Therapy, CHU Grenoble, Grenoble, France;
j
Patient Advocate, Hasselt, Belgium;
k
Academic Urology Unit, University of Sheffield,
Sheffield, UK;
l
Division of Oncology/Unit of Urology, IRCCS Ospedale San Raffaele, Vita-Salute San Raffaele University, Milan, Italy;
m
Department of Urology,
University of Bern, Inselspital, Bern, Switzerland;
n
Leeds Cancer Centre, St. James’s University Hospital and University of Leeds, Leeds, UK;
o
Department of
Pathology, Erasmus Medical Center, Rotterdam, The Netherlands;
p
N.N. Blokhin Cancer Research Center, Moscow, Russia;
q
University of Warwick, Cancer
Research Centre, Coventry, UK;
r
Department of Radiology & Nuclear Medicine, Erasmus MCUniversity Medical Center, Rotterdam, The Netherlands;
s
Department of Radiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands;
t
Department of Radiation Oncology, University Hospital Ulm,
Ulm, Germany;
u
Division of Gastroenterology and Cochrane UGPD Group, Department of Medicine, Health Sciences Centre, McMaster University, Hamilton,
Canada;
v
Royal Liverpool and Broadgreen Hospitals NHS Trust, Liverpool, UK;
w
Department of Urology, University Hospital, St. Etienne, France;
x
Academic
Urology Unit, University of Aberdeen, Aberdeen, UK;
y
Department of Urology, Aberdeen Royal Infirmary, Aberdeen, UK;
z
Universite´ Lyon 1, faculte´ de
me´decine Lyon Est, Lyon, France
E U R O P E A N U R O L O G Y 7 2 ( 2 0 1 7 ) 2 5 0 – 2 6 6available at
www.scienced irect.comjournal homepage:
www.europeanurology.comArticle info
Article history:
Accepted February 16, 2017
Associate Editor:
James Catto
Keywords:
Prostate cancer
Multiparametric magnetic
resonance imaging
Abstract
Context:
It remains unclear whether patients with a suspicion of prostate cancer (PCa)
and negative multiparametric magnetic resonance imaging (mpMRI) can safely obviate
prostate biopsy.
Objective:
To systematically review the literature assessing the negative predictive
value (NPV) of mpMRI in patients with a suspicion of PCa.
Evidence acquisition:
The Embase, Medline, and Cochrane databases were searched up
to February 2016. Studies reporting prebiopsy mpMRI results using transrectal or
transperineal biopsy as a reference standard were included. We further selected for
meta-analysis studies with at least 10-core biopsies as the reference standard, mpMRI
comprising at least T2-weighted and diffusion-weighted imaging, positive mpMRI
defined as a Prostate Imaging Reporting Data System/Likert score of 3/5 or 4/5,
y
Joint first co-authors.
* Corresponding author. Hospices Civils de Lyon, Department of Urinary and Vascular Radiology,
Hoˆpital E´ douard-Herriot, Lyon, France. Tel. +33 472 110 950; Fax: +33 472 110 954.
E-mail address:
Olivier.rouviere@netcourrier.com(O. Rouvie`re).
http://dx.doi.org/10.1016/j.eururo.2017.02.0260302-2838/
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2017 European Association of Urology. Published by Elsevier B.V. All rights reserved.