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multicriteria decision-making in nonmedical fields. The

resulting information and diagnostic and therapeutic

approaches, when applied to prostate cancer, for instance,

may have less uncertainty than when the sources are

evaluated individually and separately.

Conflicts of interest:

The authors have nothing to disclose.

References

[1]

Montironi R, Gasparrini S, Mazzucchelli R, et al. Re: KarimA. Touijer, James A. Eastham. The sentinel lymph node concept and novel approaches in detecting lymph node metastasis in prostate cancer. Eur Urol 2016;70:738–9: sentinel lymph nodes in adipose tissue surrounding the prostate gland and seminal vesicles as observed in virtual whole-mount histologic slides. Eur Urol 2017;71:e73–5.

[2]

Touijer KA, Eastham JA. The sentinel lymph node concept and novel approaches in detecting lymph node metastasis in prostate cancer. Eur Urol 2016;70:738–9.

[3]

Montironi R, Cheng L, Lopez-Beltran A, et al. Joint appraisal of the radical prostatectomy specimen by the urologist and the uropathol- ogist: together, we can do it better. Eur Urol 2009;56:951–5.

[4] Montironi R, Cheng L, Lopez-Beltran A, Scarpelli M. Quantitative

image analysis on histologic virtual slides for prostate pathology

diagnosis, response to chemopreventive agents, and prognosis. Eur

Urol Focus. In press.

http://dx.doi.org/10.1016/j.euf.2016.06.013

.

[5] Cagle PT, Glassy EF. Whole slide images add value to journal article

figures. Arch Pathol Lab Med 2014;138:592

In: http://dx.doi.org/ 10.5858/arpa.2014-0042-ED .

[6]

Ghaznavi F, Evans A, Madabhushi A, Feldman M. Digital imaging in pathology: whole-slide imaging and beyond. Annu Rev Pathol 2013;8:331–59.

[7]

Montironi MA. From image analysis in pathology to robotics and artificial intelligence. Anal Quant Cytopathol Histopathol 2016;38:268–9.

Rodolfo Montironi

a,

*

Antonio Lopez-Beltran

b

Liang Cheng

c

Silvia Gasparrini

a

[3_TD$DIFF]

Maria Alessandra Montironi

d

Francesco Massari

e

Marina Scarpelli

a

Francesco Montorsi

f

[1_TD$DIFF]

a

Section of Pathological Anatomy, Polytechnic University of the Marche

Region, School of Medicine, United Hospitals, Ancona, Italy

b

Pathology Service, Champalimaud Clinical Center, Lisbon, Portugal

c

Department of Pathology and Laboratory Medicine, Indiana University

School of Medicine, Indianapolis, IN, USA

d

Department of Mechanical and Aerospace Engineering, University of

California, Davis, CA, USA

e

Division of Oncology, S. Orsola-Malpighi Hospital, Bologna, Italy

f

Unit of Urology/Division of Oncology, Urological Research Institute, IRCCS

Ospedale San Raffaele, Milan, Italy

*Corresponding author. Section of Pathological Anatomy, Polytechnic

University of the Marche Region, School of Medicine, United Hospitals,

Via Conca 71, I-60126 Ancona, Italy. Tel. +39 071 5964830;

Fax: +39 071 889985.

E-mail address:

r.montironi@univpm.it

(R. Montironi).

February 22, 2017

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